Top 5 Shows Similar to Common Side Effects

As the first season of Common Side Effects on Adult Swim wraps up, it has already carved a niche for itself as one of the standout animated series of 2025. Created by Joseph Bennett and Steve Hely, this quirky animated conspiracy drama has captured the attention of viewers with its unique storylines and clever humor. With the recent season finale, fans may find themselves looking for similar content to satisfy their cravings for this one-of-a-kind show.

At the heart of Common Side Effects is Marshall Cuso, a mycologist who stumbles upon a mushroom capable of curing every ailment, even death itself. Unfortunately for him, this life-changing discovery places him in the crosshairs of Reutical, a colossal medical conglomerate that sees his find as a direct threat to their profit-driven model. Teaming up with Frances Applewhite, a former classmate and current Reutical employee, Marshall must navigate both the ramifications of his discovery and the potential dangers posed by the corporation.

5 The Second Best Hospital In The Galaxy

An Unconventional Animated Medical Series

Fans of Common Side Effects will likely appreciate the unique premise of The Second Best Hospital in the Galaxy available on Amazon Prime Video. This animated series stands apart by introducing viewers to a crew of alien physicians tackling bizarre intergalactic ailments. With its comedic yet episodic storytelling, this series presents a refreshing take on medical themes that both entertain and engage audiences after finishing Common Side Effects.

4 The Shivering Truth

A Dark Comedy Anthology

Another gem that warrants attention from Common Side Effects enthusiasts is The Shivering Truth, a critically acclaimed stop-motion anthology series produced by Adult Swim. This show delves into grim topics such as morality and mortality reminiscent of the darker themes explored in Common Side Effects. With its unique storytelling approach, The Shivering Truth is a must-watch for fans looking to explore the more profound aspects of animated storytelling.

3 Pantheon

A Sci-Fi Narrative with a Twist

Releasing in 2022, Pantheon is another animated series that caters to fans of Common Side Effects. This AMC+ production follows the journey of Maddie, a teenage girl who learns her deceased father’s consciousness has been uploaded to the cloud. As she unravels the complexities of her father’s fate, the show’s sci-fi and conspiracy elements echo the intrigue of Common Side Effects, making it an engaging watch.

2 Inside Job

A Conspiracy-Themed Comedy Series on Netflix

For those drawn to conspiracy narratives, Inside Job on Netflix provides a humorous spin on such themes. Centered around Cognito, Inc., an organization that covertly governs global affairs, the show satirizes real-life conspiracy theories. With its intricate, comedic representations of popular conspiracies like the existence of hollow Earth and reptilian overlords, Inside Job offers a lighthearted complement to the more serious undertones of Common Side Effects.

1 Scavengers Reign

The Preceding Work of Joseph Bennett

Finally, fans of Common Side Effects should not miss Scavengers Reign, another captivating creation by Joseph Bennett alongside co-creator Charles Huettner. Premiering in 2023, this sci-fi animated series follows the survivors of a cargo spaceship stranded on an alien world. Their survival entails navigating the surreal alien ecosystem of the planet Vesta while plotting their way back home. Unfortunately, despite positive critical feedback, Max canceled Scavengers Reign after its inaugural season, leaving a void for devoted fans of Bennett’s imaginative storytelling.

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