Over the span of Grey’s Anatomy‘s impressive 21 seasons, audiences have witnessed the comings and goings of numerous characters, including fan-favorite Cristina Yang, portrayed by Sandra Oh. With the series continuing to captivate viewers, speculation about her potential return has intensified. The ABC medical drama, known for its dynamic cast, frequently sees doctors transition in and out of Grey Sloan Memorial Hospital. Currently, amidst Grey’s Anatomy’s 21st season, only Ellen Pompeo’s Meredith Grey remains from the original ensemble, albeit in a reduced capacity. The rest of the original characters, like Cristina, have either departed through narrative arcs or tragic circumstances.
New episodes of Grey’s Anatomy air on Thursdays at 10 PM ET on ABC, following 9-1-1 Season 8 at 8 PM ET, and Doctor Odyssey Season 1 at 9 PM ET.
Cristina Yang was part of the iconic original five interns when Grey’s Anatomy premiered, alongside Meredith, Izzie Stevens, Alex Karev, and George O’Malley. Oh was a staple of the series until the conclusion of Season 10, when she left to accept a prestigious position at the Klausman Institute for Medical Research in Zurich. With ten seasons and 220 episodes under her belt, Cristina remains a legendary figure within the Grey’s Anatomy lore. The prospect of her return carries significant weight for fans and the series alike.
Sandra Oh Expresses Increased Openness to Returning as Cristina Yang
Oh Previously Dismissed the Idea of Reprising Her Role

For years, Sandra Oh firmly resisted the notion of revisiting her role as Cristina Yang. However, her perspective has begun to shift. In a recent interview with Entertainment Weekly, she reflected on her journey with the character and acknowledged the deep affinity viewers have for Cristina. She stated:
“I am glad for the show to use the character as they see fit. Absolutely. The character should still be there to service the story— and so, yay! As for actually physically inhabiting the character of Cristina and coming back…. For the longest time, it has always been a hard no. And it’s just…. I don’t know. I just don’t know. When you finish something, it’s a deep process…. I just cannot tell you…. I can’t stress to you enough how consciously I tried to fully process leaving. I don’t feel the need to revisit, but I also profoundly understand the audience’s love for this character, because I’ve seen it for the past 10 years. That’s the part that makes me just go, hmmm.”
While Oh used to respond with a definitive “hard no”when asked about returning to the beloved series, her recent admissions reveal a willingness to reconsider the idea. Even though she does not currently feel compelled to revisit her storyline, the evolving dynamics mean that a return is more feasible than ever. This shift in perspective opens doors for her to potentially return to a series that holds a significant place in her history.
Recent Character Returns in Grey’s Anatomy Signal Cristina’s Possible Comeback
Notable Returns of Iconic Characters in Recent Seasons

Season 17 of Grey’s Anatomy reintroduced various beloved characters, cementing the idea that Cristina Yang can easily return. This trend was largely influenced by the COVID-19 pandemic, which prompted innovative storytelling methods. During a key narrative moment, Meredith Grey experienced a coma and dreamt of her deceased loved ones, including Patrick Dempsey’s Derek Shepherd, George O’Malley, Lexie Grey, and Mark Sloan, all of whom encountered her in a surreal beach setting.
With Oh now expressing a newfound willingness to return, the production team at Grey’s Anatomy must capitalize on this favorable development. In addition to Cristina’s potential return, Sarah Drew has reprised her role as April Kepner, Kate Walsh made a comeback as Addison Montgomery, and Jesse Williams returned as Jackson Avery in the latest season. If the writers can devise plausible scenarios for the return of these fan-favorites, creating a narrative that includes Cristina’s comeback would be entirely feasible.
Exploring the Mechanisms of Cristina Yang’s Return to Grey’s Anatomy
Possible Reasons for Cristina’s Return, Particularly for Meredith

The enduring bond between Cristina and Meredith has remained a focal point of the series, even in Sandra Oh’s absence. Through letters and subtle references, Cristina continues to have a presence within the story. Therefore, crafting an engaging narrative that facilitates her return in upcoming episodes should be achievable. It’s plausible that such a return would correlate closely with Meredith’s circumstances, reinforcing Ellen Pompeo’s involvement in the storyline.
One potential storyline could involve Meredith seeking Cristina’s expertise in her ongoing Alzheimer’s research. Alternatively, a dramatic event might necessitate Cristina’s return to Seattle. It’s important to remember the unpredictable nature of Grey’s Anatomy. Fans may find themselves awaiting the arrival of Season 22 to discover if and under what circumstances Sandra Oh will reprise her iconic role.
Source: Entertainment Weekly