Investing in an efficient Cyte-09 build can greatly enhance your experience in Warframe, especially for players aiming for high clear speeds. While Cyte-09 might initially appear to be a marksman-focused Warframe, his capabilities extend far beyond single-target damage. When equipped with the right weapon — specifically the Sobek — it’s possible for Cyte-09 to consistently achieve kill rates of 200 enemies per minute or more.
This guide aims to outline Cyte-09’s abilities, optimal builds, recommended weapons, and useful Helminth synergies to maximize your gameplay strategy.
Understanding Cyte-09’s Abilities: A Comprehensive Overview

For a quick understanding of how to construct a formidable Cyte-09 build, let’s break down his key Warframe abilities:
- Seek: This powerful ability acts as a crowd-clearing tool by bypassing line-of-sight restrictions. It reveals enemy weak points through walls—similar to Zenith—and grants guns a 10-meter body Punch Through as well as infinite Terrain Punch Through. This means you can effectively hold a position where enemies struggle to reach you while dispatching them effortlessly.
- Resupply: When held down, it brings up a gear wheel for elemental choices for your magazine. Hitting the button releases that element for the rest of the mission. This functionality resembles Saryn’s Toxic Lash because the Resupply element operates independently of your modded elements, triggering a separate damage instance with each hit—allowing for critical and status procs without affecting your existing damage.
- Evade: This grants invisibility as long as you chain weak-point kills. However, failing to maintain the chain results in a considerable 60-second cooldown, making Evade a bit trickier to optimize compared to standard invisibility methods. The countdown starts as soon as Evade is activated, enabling you to recast the ability immediately after it expires if timed correctly. Moreover, both base duration and the increment from kills are affected by Ability Duration mods.
- Neutralize: This enables your exalted sniper rifle with significant power, boasting an effective range of 600m and initiating damage falloff only at 400m. Its alternate fire launches a cold grenade that freezes nearby enemies, facilitating easy headshots. Additionally, kills from weak-point shots cause ricochets to up to four enemies. While it has great potential, in this build, we will focus more on the Sobek than the Neutralizer.
Don’t have Cyte-09 unlocked yet? Here’s how to obtain him.
Optimal Cyte-09 Build for Endgame Content
For a successful Cyte-09 build, emphasize Ability Strength for high damage output and Duration to streamline your ability rotations. Our recommended build statistics are as follows:
- 242% Duration
- 50% Efficiency
- 115% Range
- 245% Strength (or 305% with Molt Augmented)
Ability Modifier Analysis
Increasing Duration helps to maintain your abilities longer between recasts, making it easier to manage Evade. While you could swap some Duration for extra Strength, keep in mind that you don’t need much Ability Range. Range mainly extends Seek’s effective coverage—its base radius is already 60 meters, exceeding typical engagement ranges in Warframe—and since the Sobek is a shotgun, you’ll prioritize nearby targets due to damage falloff.
Cyte-09 Mod Configuration (Single Forma)

Essential Mods:
- Aura Slot: Dead Eye (or Shotgun Amp for exact setups)
- Energy Nexus
- Stretch
- Narrow Minded (D polarity, default)
- Augur Message (replace with Augur Secrets for reduced Duration)
- Transient Fortitude (V polarity, default)
- Blind Rage (V polarity, requires Forma)
- Primed Continuity
- Augur Reach
Recommended Arcanes:
- Molt Augmented: This build can hit 250 kills in the initial two minutes, effectively granting 60% extra Strength.
- Arcane Crepuscule: Increases Sobek’s damage as long as Evade is maintained. Alternatives include Arcane Tempo (for shotguns), Arcane Rage, or Arcane Acceleration, depending on weapon preferences.
Archon Shard Recommendations:
Cyte-09 is functional without Archon Shards, but for synergy with Sobek, we recommend five Violet Archon Shards to enhance primary Electricity damage. Alternatively, use Crimson Archon Shards for a general boost to Ability Strength or Duration.
Best Weapon for Cyte-09: Synergy with Sobek

The Sobek, especially the Kuva Sobek variant, is the ideal weapon to complement Cyte-09’s abilities due to the unique Acid Shells mod that synergizes with the additional damage from Resupply. When an enemy is killed, Acid Shells creates an explosion that deals 45% of that enemy’s health within a 15-meter radius.
Importantly, the additional damage from Resupply applies to this explosive damage instance, with guaranteed status activation. For optimal results, use Electricity with Resupply to maximize damage through Acid Shells’ explosions, as it scales exceptionally well with mod effects.
Recommended Sobek Mods (5 Forma):
- Galvanized Hell
- Acid Shells
- Primed Ravage
- Galvanized Savvy
- Primed Charged Shell
- Clip Delegation (or Primed/regular Point Blank if needed)
- Shotgun Elementalist
- Primed Cleanse mod (or regular if Primed isn’t available)
- Exilus: Galvanized Acceleration
- Arcane: Primary Deadhead
When using Kuva Sobek, choose a +Toxin or +Cold progenitor to yield Corrosive or Magnetic damage types, both of which effectively amplify damage on this build through Primed Charged Shell.
Additional Weapon Recommendations:
This Sobek build is powerful enough to take down Acolytes in Steel Path with ease. Alternative choices for single-target encounters include the Laetum, or, for those looking to enhance Resupply’s end damage, consider running Grimoire combined with Vome Invocation. Be sure to pair your setup with a companion like an Adarza Cavat to capitalize on increased critical chances.
Optimal Helminth Choices for Cyte-09

While Resupply serves as a versatile damage buff, substituting it for options like Roar or Eclipse is counterproductive due to the unique utility it provides. For alternative Helminth abilities that pair well with Cyte-09, consider the following options:
- Nourish: This ability doubles as a Viral and elemental buff and aligns seamlessly with Resupply, which is beneficial despite the lack of need for energy management.
- Pillage: Offers a way to strip armor while providing a shield for more challenging Steel Path engagements. Swapping Evade for this may require a different build focused on Primed Redirection.
- Ensnare: This ability provides crowd control and aligns enemies perfectly for headshots, although it may require additional Range mods for enhanced effectivity.
- Silence: Complements Cyte-09’s tactical gameplay, particularly useful against specific foes or situations requiring suppressive strategies.
Gameplay Strategy for Cyte-09 with This Build

When utilizing the Cyte-09 and Sobek combo outlined in this guide, here’s a recommended gameplay approach: First, hold down Resupply to select Electricity, then find a suitable spot to hold your position while engaging enemies from safety. Utilize the Seek ability to reveal weak points on enemies safely while firing through cover.
- Utilize Resupply to refresh your ammo instead of reloading, with caution as this may occasionally break Clip Delegation.
- Activating Evade boosts damage potential thanks to your Arcane Crepuscule.
- If using Nourish, activate it to optimize energy sustainability, although the build inherently possesses a strong energy economy.
- You may also adopt a run-and-gun style, but keep Evade active to compensate for default vulnerabilities.
This build excels in endless game modes, particularly since shotgun weak-point mechanics require a ramp-up period for critical damage benefits. Once established, it becomes effective even in late-game scenarios across Disruption, Defense, Cascade, and Survival modes.
Budget-Friendly 1-Forma Neutralizer Build for Cyte-09

While the Neutralizer isn’t necessary for the main recommended build, here’s a simple, cost-effective 1-Forma build for players interested in using it:
Essential Mods:
- Semi-Fire Cannonade
- Galvanized Aptitude (or Hammer Shot)
- Galvanized Scope
- Critical Delay
- Galvanized Chamber
- Malignant Force Rank 0
- Rime Rounds
- Vital Sense
- Arcane: Primary Deadhead
For further information and visuals on building Cyte-09, feel free to refer to the source linked below.