The Coda Pox in Warframe may not be the top-performing weapon, but it can hold its own in Steel Path missions with an optimal setup. Comparable to the standard Pox and lacking the Incarnon glow-up, this throwable secondary weapon utilizes a poison cloud mechanic. It gains considerable synergy with the new Secondary Enervate Arcane, offering surprising interactions with Damage over Time (DoT) effects.
To maximize the effectiveness of the Coda Pox, players should focus on building around its group damage capabilities.
Enhancing Coda Pox: Building for Group Synergy

The unique feature of the Coda Pox lies in its ability to create a toxic cloud that inflicts area damage. When it successfully hits an enemy, the resultant cloud generates a DoT effect, applying critical hits and status effects independent of the weapon’s stats. Notably, any buffs active at the time of the cloud’s creation will persist throughout its duration, enhancing its overall effectiveness.
However, without the cloud, the Coda Pox performs rather poorly as a thrown secondary weapon. To fully utilize its potential, players are encouraged to employ methods for gathering enemies together. This can be achieved using abilities from the Helminth system or innate Warframe abilities, like Ensnare or Coil Horizon. Alternatively, the Nautilus companion can effectively round up foes.
Optimal Coda Sporothrix Loadout for Endgame Challenges (5 Forma)

To fully harness the capabilities of this Coda weapon, a 5 Forma investment is necessary to unlock its mastery potential. This build leverages the Coda Pox’s signature cloud mechanic to its fullest, prioritizing enemy groupings.
When it comes to elemental choices, Blast stands out as the optimal option. For this reason, incorporating a Cold Progenitor is essential, allowing the use of Primed Heated Charge to generate the Blast effect. Additionally, players can swap two mods to transition towards a Viral-Gas build. Below is an outline of the recommended mods and the relationship with this loadout:
Recommended Mods
- Hornet Strike (V Forma)
- Pistol Elementalist (D Forma)
- Pistol Pestilence
- Jolt
- Galvanized Diffusion (V Forma)
- Primed Heated Charge (Dash Forma)
- Primed Fulmination (Use Frostbite if utilizing a Magnetic Progenitor)
- Primed Target Cracker (V Forma)
Arcane Recommendation
Secondary Enervate forms the core of this build.
As previously noted, the Coda Pox’s cloud inherits stats at the moment of its proccing. This allows players to effectively “snapshot”the cloud with maximum Enervate stacks before they reset, leading to impressive red crits. While this setup might not work in standard missions, it provides a significant boost to an otherwise underwhelming Coda weapon.